Men, Covid-19, the pandemic, and stressful life events – not a good mix. So much has happened since I last updated my blog. It has been an intense and difficult time for so many of us for so many different reasons, both related to COVID-19, other work commitments and life events that none can predict, but can hit hard. This blog tries to give an update on what’s been happening in my life since the start of 2020. COVID-19 and pandemic What became clear early on in the pandemic was the higher rates of severe disease and death in men. Working with the Men’s Health Forum [www.menshealthforum.org.uk] there was a need to understand what was going on. A key factor appeared to be a very complex biological sex differences in the immune system, which we tried to explain in one of papers we managed to get published over the year(1). We also held a number of webinars (with the Men’s Health Forum [GB], Men’s Health Forum [Ireland], Global Action on Men’s Health [GAMH] and for the journal Trends in